Liver function
Total protein blood test
A total protein blood test measures the combined amount of albumin and globulin, the two main groups of protein in your blood. It's a broad marker of nutrition, liver and kidney function and immune activity, and it's most informative when read alongside its albumin and globulin components.
- What it measures
- The total of albumin and globulin proteins in your blood
- Sample
- Venous blood sample
- Fasting
- Not required
- Also known as
- serum total protein
- Included in 57 Health tests
- 3 panels, from £95
Total protein reference range
Guide only| Category | Guide range |
|---|---|
| Adults | 60–80 g/L |
Total protein is the sum of albumin and globulin, so it's interpreted alongside both. It's affected by hydration (dehydration can raise it), as well as liver, kidney and nutritional status. Ranges vary by laboratory.
These are general UK adult guide ranges from public health sources, shown for orientation only. Reference ranges vary by laboratory, assay, age and sex, so your result is always interpreted against the range quoted by the analysing laboratory on your report.
What does a high total protein level mean?
A high total protein can simply reflect dehydration, but it can also indicate chronic inflammation or infection, or conditions that increase antibody production.
Because it's a broad measure, a raised result is interpreted with albumin, globulin and, where needed, further tests.
What does a low total protein level mean?
A low total protein can reflect poor nutrition, liver conditions (reduced protein production), or protein loss through the kidneys or gut.
The albumin and globulin breakdown helps show which protein is low and why.
When to consider a total protein test
- As part of a general health check
- Assessing nutrition, liver or kidney health
- Investigating swelling (oedema) or unexplained symptoms
- Following up an abnormal albumin or globulin result
Frequently asked questions
This page is general information about a blood marker and is not medical advice or a diagnosis. A total protein test screens and gives context; results are interpreted by a clinician alongside your symptoms, history and other markers. Always follow the guidance on your own report.