Liver function
Globulin blood test
Globulins are a group of proteins in your blood that include antibodies and transport and clotting proteins. A globulin blood test (usually calculated as total protein minus albumin) gives a broad signal about your immune activity, inflammation and liver function, interpreted alongside albumin and total protein.
- What it measures
- Globulins, a group of immune, transport and clotting proteins
- Sample
- Venous blood sample
- Fasting
- Not required
- Also known as
- serum globulin, total globulin
- Included in 57 Health tests
- 3 panels, from £95
Globulin reference range
Guide only| Category | Guide range |
|---|---|
| Adults | 18–36 g/L |
Globulin is usually calculated as total protein minus albumin, so it's read together with both. Ranges vary by laboratory, and the albumin-to-globulin (A/G) ratio can add context.
These are general UK adult guide ranges from public health sources, shown for orientation only. Reference ranges vary by laboratory, assay, age and sex, so your result is always interpreted against the range quoted by the analysing laboratory on your report.
What does a high globulin level mean?
A high globulin often reflects the immune system responding to chronic infection or inflammation, and it can occasionally point to conditions affecting antibody-producing cells or the liver.
It's a broad signal rather than a diagnosis, so a raised globulin is interpreted with albumin, total protein and, if needed, further tests such as protein electrophoresis.
What does a low globulin level mean?
A low globulin is less common and can relate to reduced antibody production or protein loss (for example through the kidneys or gut).
It's interpreted alongside albumin and your other results rather than on its own.
When to consider a globulin test
- As part of a general health or liver panel
- Investigating chronic infection or inflammation
- Unexplained fatigue or weight change
- Following up an abnormal total protein result
Frequently asked questions
This page is general information about a blood marker and is not medical advice or a diagnosis. A globulin test screens and gives context; results are interpreted by a clinician alongside your symptoms, history and other markers. Always follow the guidance on your own report.